Article
Braf Mutations Initiate the Development of Rat Gliomas Induced by Postnatal Exposure to N-Ethyl-N-Nitrosourea.
The American journal of pathology - 1 Oct 2016
Wang Qi, Satomi Kaishi, Oh Ji Eun, Hutter Barbara, Brors Benedikt, Diessl Nicolle, Liu Hai-Kun, Wolf Stephan, Wiestler Otmar, Kleihues Paul, Koelsch Bernd, Kindler-Röhrborn Andrea, Ohgaki Hiroko
Abstract excerpt
A single dose of N-ethyl-N-nitrosourea (ENU) during late prenatal or early postnatal development induces a high incidence of malignant schwannomas and gliomas in rats. Although T->A mutations in the transmembrane domain of the Neu (c-ErbB-2) gene are the driver mutations in ENU-induced malignant schwannomas, the molecular basis of ENU-induced gliomas remains enigmatic. We performed whole-genome sequencing of...
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