Article
Cholinergic differentiation of cultured sympathetic neurons induced by retinoic acid. Induction of choline acetyltransferase-mRNA and suppression of tyrosine hydroxylase-mRNA levels.
FEBS letters - 17 Jan 1994
Kobayashi M, Matsuoka I, Kurihara K
Abstract excerpt
Here we show that retinoic acid (RA) has the ability to alter the transmitter phenotype of cultured sympathetic neurons from newborn rats superior cervical ganglia (SCG). In the presence of RA, the level of choline acetyltransferase (ChAT) mRNA was increased, while the level of tyrosine hydroxyla...
Topics
- Animals
- Animals, Newborn
- Base Sequence
- Cell Differentiation
- Cells, Cultured
- Choline
- Choline O-Acetyltransferase
- Ganglia, Sympathetic
- Growth Inhibitors
- Interleukin-6
- Leukemia Inhibitory Factor
- Lymphokines
- Molecular Sequence Data
- Nerve Growth Factors
- Nerve Tissue Proteins
- Neurons
- Phenotype
- Polymerase Chain Reaction