Article
Retinoic acid induces cholinergic differentiation of cultured newborn rat sympathetic neurons.
Journal of neuroscience research - 1 Jul 1993
Berrard S, Faucon Biguet N, Houhou L, Lamouroux A, Mallet J
Abstract excerpt
Many studies provide evidence that retinoic acid (RA), an endogenous derivative of vitamin A, plays a role in the development of the nervous system. We now report that RA controls the neurotransmitter phenotype of post-mitotic rat sympathetic neurons in cell culture. RA added to the culture mediu...
Topics
- Acetylcholine
- Animals
- Animals, Newborn
- Cell Differentiation
- Cells, Cultured
- Choline O-Acetyltransferase
- Dopamine beta-Hydroxylase
- Ganglia, Spinal
- Neuronal Plasticity
- Norepinephrine
- Parasympathetic Nervous System
- Phenotype
- Rats
- Rats, Wistar
- Sympathetic Nervous System
- Tretinoin
- Tyrosine 3-Monooxygenase