Article

Retinoic acid modulates the level of nerve growth factor gene expression and proliferation of cultured human keratinocytes

2002-12-01

Abstract excerpt

Retinoic acid (RA) inhibited proliferation of cultured human keratinocytes. Southern blot analysis at 24 h showed that RA inhibited nerve growth factor (NGF) mRNA synthesis in a dose-dependent manner. However, RA stimulated the production of NGF protein up to 187% of control after 96 h and the treatment of cells with RA did not enhance apoptosis, either in the presence of low or high concentration of Ca(2+), when...

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Literature Corpus work: 3cebdaf1-c830-55a6-a172-dfffc72a2e11
DOI: 10.1023/a:1021363203406

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