Article
c-Ha-ras BamHI RFLP in human urothelial tumors and point mutations in hot codons.
Neoplasma - 1 Jan 1993
Weismanová E, Kalúz S, Skorvaga M
Abstract excerpt
High-molecular-weight DNAs from 30 bladder and renal cell carcinomas (RCC) were isolated and the c-Ha-ras gene BamHI RFLP was examined. Amplification of c-Ha-ras with normal localization with regard to the size of alleles was found only in one case. One of the normally localized c-Ha-ras allele termed RCC c-Ha-ras of a length of about 6.6 kbp was cloned and an oncogene-activating point mutation was identified...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
