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Restriction fragment length polymorphism and activation of c-Ha-ras gene in urothelial cancer.

Anticancer research - 1 Jan 2000

Ishikawa J, Maeda S, Kamidono S, Sugiyama T

Abstract excerpt

The human c-Ha-ras gene shows restriction length polymorphism (RFLP) due to the variable tandem repetition (VTR) of DNA sequences in the 3'-flanking region. It was suggested that RFLP of the c-Ha-ras gene may be useful in detecting individuals at risk of cancer. In vitro studies showed transcriptional enhancer and promoter activities in the VTR region. In some human tumors, the loss of one c-Ha-ras allele is...

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PMID: 2902823

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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