Article
Restriction digest PCR (RD-PCR) for the analysis of gene mutations. Application to Ki-ras.
Clinical chemistry and laboratory medicine - 1 Aug 1998
Huber K R, Bittner J, Bauer K, Trümper L, Sek A, Sebesta C, Rosen H, Tragl K H
Abstract excerpt
The Kirsten-ras (onco)gene codes for a GTP-binding membrane protein that is involved in signal transduction. Activated ras triggers a cascade of protein-phosphorylations that ultimately lead to cell proliferation. Ras-mutations are the main cause for adenocarcinomas of the pancreas besides some mutations in the tumor suppressor gene p53 and the c-erbB-2 oncogene. The site of ras mutations in pancreatic cancer is...
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