Article
Murine monoclonal antibody recognizing a 90-kDa cell-surface determinant selectively lost by multi-drug-resistant variants of CEM cells.
International journal of cancer - 15 Jan 1990
Cianfriglia M, Cenciarelli C, Tombesi M, Barca S, Mariani M, Morrone S, Santoni A, Samoggia P, Alessio M, Malavasi F
Abstract excerpt
We describe a murine IgG1 monoclonal antibody (MAb56), specific for a cell-surface protein structure (MC56 determinant) expressed by the human CEM cell line. A large band of approximately 90 kDa was identified as the main specific component of the MC56 determinant. Such a 90-kDa protein is signif...
Topics
- Animals
- Antibodies, Monoclonal
- Antibody Specificity
- Antigens, Surface
- Cell Line
- Drug Resistance
- Epitopes
- Humans
- Hybridomas
- Immunoglobulin G
- Mice
- Molecular Weight
- Phenotype
- Precursor Cell Lymphoblastic Leukemia-Lymphoma
- Tumor Cells, Cultured