Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Overexpression of a Transporter Gene in a Multidrug-Resistant Human Lung Cancer Cell Line

4 Dec 1992

Abstract excerpt

The doxorubicin-selected lung cancer cell line H69AR is resistant to many chemotherapeutic agents. However, like most tumor samples from individuals with this disease, it does not overexpress P-glycoprotein, a transmembrane transport protein that is dependent on adenosine triphosphate (ATP) and is associated with multidrug resistance. Complementary DNA (cDNA) clones corresponding to messenger RNAs (mRNAs)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA and Nucleic Acid Chemistry
Share to Drug Transport and Resistance Mechanisms
Share to Pediatric Hepatobiliary Diseases and Treatments

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 1360704
DOI: 10.1126/science.1360704

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Overexpression of a Transporter Gene in a Multidrug-Resistant Human Lung Cancer Cell LinePMID 1360704Read ↗

Atypical Multidrug Resistance: Breast Cancer Resistance Protein Messenger RNA Expression in Mitoxantrone-Selected Cell LinesSemantic proximity Read ↗

A multidrug resistance transporter from human MCF-7 breast cancer cellsSemantic proximity Read ↗

Expression of the multidrug resistance-associated protein (MRP) and chemoresistance of human non-small-cell lung cancer cellsSemantic proximity Read ↗

Multidrug resistance and the lung resistance-related protein in human colon carcinoma SW-620 cells.Semantic proximity Read ↗

Multidrug resistance in a small cell lung cancer line: rapid selection with etoposide and differential chemosensitization with cyclosporin A.Semantic proximity Read ↗

Reduced drug accumulation and multidrug resistance in human breast cancer cells without associated P-glycoprotein or MRP overexpression.Semantic proximity Read ↗

Utilizing non-coding RNA-mediated regulation of ATP binding cassette (ABC) transporters to overcome multidrug resistance to cancer chemotherapySemantic proximity Read ↗

Analysis of the expression of MRP, the gene for a new putative transmembrane drug transporter, in human multidrug resistant lung cancer cell linesSemantic proximity Read ↗

Overexpression of P-glycoprotein but not its mRNA in multidrug resistant cells selected with hydroxyrubicin.Semantic proximity Read ↗

Altered expression of mRNAs for apoptosis-modulating proteins in a low level multidrug resistant variant of a human lung carcinoma cell line that also expresses mdr1 mRNA.Semantic proximity Read ↗

Overexpression of mutated MRP4 in cisplatin resistant small cell lung cancer cell line: collateral sensitivity to azidothymidine.Semantic proximity Read ↗

mdr1 ribozyme mediated reversal of the multi-drug resistant phenotype in human lung cell lines.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.