Article
Reversal of an interferon-gamma-resistant phenotype by poly(I:C): possible role of double-stranded RNA-activated kinase in interferon-gamma signaling.
Journal of interferon research - 1 Aug 1993
Ozes O N, Taylor M W
Abstract excerpt
Indoleamine 2,3-dioxygenase (IDO) is induced in neoplastic cell lines by interferon-gamma (IFN-gamma) treatment. In ME180 cervical carcinoma cells, there is a rapid increase in IDO mRNA accumulation beginning at 4 h after IFN-gamma treatment and continuing for at least 24 h. The IFN-gamma-resista...
Topics
- Drug Resistance
- Enzyme Activation
- Histones
- Humans
- Interferon-gamma
- Mutation
- Phenotype
- Phosphorylation
- Poly I-C
- Promoter Regions, Genetic
- Protein Serine-Threonine Kinases
- RNA, Double-Stranded
- Signal Transduction
- Transfection
- Tumor Cells, Cultured
- eIF-2 Kinase