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The effects of interferon on the expression of human papillomavirus oncogenes

1 Mar 2000

Abstract excerpt

The effects of interferon (IFN)-alpha, IFN-beta and IFN-gamma on human papillomavirus (HPV) oncogene expression were studied in various cervical carcinoma cell lines containing integrated copies of either HPV type 16 or HPV type 18. The levels of E6 and E7 transcripts were examined 6 h and 30 h after treatment with IFN. In HeLa cells, all three classes of IFNs effected a decrease in the level of HPV-18 E6 and E7...

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PMID: 10675406
DOI: 10.1099/0022-1317-81-3-695

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