Article
IDO mutants cross resistant to type I interferon retain p91-dependent gene induction.
Journal of interferon research - 1 Dec 1994
Klein S B, Yeivin A, Becker G, Taylor M W
Abstract excerpt
Genetic analyses of mutants have yielded valuable information about p91-associated interferon signal transduction. It was thus discovered that p91 is an essential protein for the induction of both type I and type II interferons. We previously reported the development of ME180 mutants resistant to interferon-gamma because of a signaling defect resulting in the loss of IDO induction. IDO does not respond to type I...
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