Article
IDO mutants cross resistant to type I interferon retain p91-dependent gene induction.
Journal of interferon research - 1 Dec 1994
Klein S B, Yeivin A, Becker G, Taylor M W
Abstract excerpt
Genetic analyses of mutants have yielded valuable information about p91-associated interferon signal transduction. It was thus discovered that p91 is an essential protein for the induction of both type I and type II interferons. We previously reported the development of ME180 mutants resistant to...
Topics
- Cell Division
- DNA-Binding Proteins
- Drug Resistance
- Gene Expression Regulation, Neoplastic
- Humans
- Indoleamine-Pyrrole 2,3,-Dioxygenase
- Interferon-alpha
- Mutation
- Neoplasm Proteins
- Phosphorylation
- RNA, Messenger
- STAT1 Transcription Factor
- Signal Transduction
- Trans-Activators
- Transcriptional Activation
- Tryptophan Oxygenase
- Tumor Cells, Cultured