Article
Interferon alpha2b differentially affects proliferation of two human renal cell carcinoma cell lines differing in the P-glycoprotein-associated multidrug-resistant phenotype.
Journal of cancer research and clinical oncology - 1 Jan 1999
Frank M H, Pomer S
Abstract excerpt
PURPOSE: Interferon alpha (IFNalpha) has been used in the immunotherapy of renal cell carcinoma (RCC), but the various mechanisms of its antiproliferative effects are poorly understood. Recent evidence suggests that IFNalpha is involved in the up-regulation of multidrug resistance (MDR) gene expression, and that the MDR gene product, P-glycoprotein (Pgp). facilitates the transport of several cytokines, some of...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Antineoplastic Agents
- Carcinoma, Renal Cell
- Cell Division
- Drug Resistance, Multiple
- Drug Resistance, Neoplasm
- Gene Expression Regulation, Neoplastic
- Humans
- Interferon alpha-2
- Interferon-alpha
- Kidney Neoplasms
- Phenotype
- Recombinant Proteins
- Tumor Cells, Cultured