Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The interferon-induced double-stranded RNA-activated protein kinase induces apoptosis.

Virology - 1 Mar 1994

Lee S B, Esteban M

Abstract excerpt

Interferons (IFNs) exert antitumor activities, but the molecular mechanism underlying these effects is poorly understood. IFN-induced, double-stranded (ds) RNA-activated protein kinase (p68 kinase) has long been implicated in mediating the antiproliferative effects of IFN. In addition, recent studies suggest that p68 kinase may function as a tumor suppressor gene. In this investigation we showed that expression...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apoptosis
Share to eIF-2 Kinase
Share to HeLa Cells

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Interferons

Share to Mutation

Share to Protein Serine-Threonine Kinases

Share to Recombinant Proteins

Share to Vaccinia virus

Source

Identifiers

PMID: 7510087
DOI: 10.1006/viro.1994.1151

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The interferon-induced double-stranded RNA-activated protein kinase induces apoptosis.PMID 7510087Read ↗

Malignant transformation by a mutant of the IFN-inducible dsRNA-dependent protein kinase.Semantic proximity Read ↗

Double-stranded-RNA-activated protein kinase PKR enhances transcriptional activation by tumor suppressor p53.Semantic proximity Read ↗

Dual Role of p53 in Innate Antiviral ImmunitySemantic proximity Read ↗

Interferon‑α and its effects on cancer cell apoptosis (Review)Semantic proximity Read ↗

The Interferon Stimulated Gene 54 Promotes ApoptosisSemantic proximity Read ↗

Induction of protein kinase PKR-dependent activation of interferon regulatory factor 3 by vaccinia virus occurs through adapter IPS-1 signaling.Semantic proximity Read ↗

Involvement of the double-stranded-RNA-dependent kinase PKR in interferon expression and interferon-mediated antiviral activity.Semantic proximity Read ↗

Inhibition of double-stranded RNA- and tumor necrosis factor alpha-mediated apoptosis by tetratricopeptide repeat protein and cochaperone P58(IPK).Semantic proximity Read ↗

Identification of functional domains of the interferon-induced enzyme PKR in cells lacking endogenous PKR.Semantic proximity Read ↗

Sequential Cdk1 and Plk1 phosphorylation of caspase-8 triggers apoptotic cell death during mitosis.Semantic proximity Read ↗

Dominant Negative Function by an Alternatively Spliced Form of the Interferon-inducible Protein Kinase PKRSemantic proximity Read ↗

Type I interferons are essential mediators of apoptotic death in virally infected cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.