Article
Human immunodeficiency virus Vpx is required for the early phase of replication in peripheral blood mononuclear cells.
Microbiology and immunology - 1 Jan 1994
Kawamura M, Sakai H, Adachi A
Abstract excerpt
Functional importance of Vpx protein of human immunodeficiency virus type 2 was evaluated in various types of cells. In 8 lymphocytic or monocytic cell lines tested, vpx mutant virus grew as well as wild-type virus. Only in primary peripheral blood mononuclear cell cultures, severely retarded gro...
Topics
- Cell Line
- Chloramphenicol O-Acetyltransferase
- Cloning, Molecular
- HIV-2
- Humans
- Leukocytes, Mononuclear
- Lymphocytes
- Monocytes
- Mutation
- Retroviridae Proteins
- Transcription, Genetic
- Viral Regulatory and Accessory Proteins