Article
Human immunodeficiency virus Vpx is required for the early phase of replication in peripheral blood mononuclear cells.
Microbiology and immunology - 1 Jan 1994
Kawamura M, Sakai H, Adachi A
Abstract excerpt
Functional importance of Vpx protein of human immunodeficiency virus type 2 was evaluated in various types of cells. In 8 lymphocytic or monocytic cell lines tested, vpx mutant virus grew as well as wild-type virus. Only in primary peripheral blood mononuclear cell cultures, severely retarded growth of mutant virus was observed. No replication of vpx-minus virus was detected in primary macrophage cells. A highly...
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