Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Vpx Is Critical for Reverse Transcription of the Human Immunodeficiency Virus Type 2 Genome in Macrophages

22 May 2008

Abstract excerpt

The abilities of wild-type and vpx-defective human immunodeficiency virus type 2 (HIV-2) clones to synthesize viral DNA in human monocyte-derived macrophages (MDMs) and lymphocytic cells were comparatively and quantitatively evaluated. While the vpx-defective mutant directed the synthesis of viral DNA comparably to the wild-type virus and normally in lymphocytic cells, no appreciable viral DNA was detected in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to HIV/AIDS drug development and treatment
Share to HIV Research and Treatment
Share to Immune Cell Function and Interaction

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 18495778
DOI: 10.1128/jvi.01003-07

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Vpx Is Critical for Reverse Transcription of the Human Immunodeficiency Virus Type 2 Genome in MacrophagesPMID 18495778Read ↗

The vpx gene of simian immunodeficiency virus facilitates efficient viral replication in fresh lymphocytes and macrophageSemantic proximity Read ↗

Functional region mapping of HIV-2 Vpx protein.Semantic proximity Read ↗

Evidence for an Activation Domain at the Amino Terminus of Simian Immunodeficiency Virus VpxSemantic proximity Read ↗

Human immunodeficiency virus Vpx is required for the early phase of replication in peripheral blood mononuclear cells.Semantic proximity Read ↗

Characterization of Simian Immunodeficiency Virus SIV <sub>SM</sub> /Human Immunodeficiency Virus Type 2 Vpx Function in Human Myeloid CellsSemantic proximity Read ↗

The Human Immunodeficiency Virus Type 2 Vpx Protein Usurps the CUL4A-DDB1 DCAF1 Ubiquitin Ligase To Overcome a Postentry Block in Macrophage InfectionSemantic proximity Read ↗

Distinct Effects in Primary Macrophages and Lymphocytes of the Human Immunodeficiency Virus Type 1 Accessory Genes vpr, vpu, and nef: Mutational Analysis of a Primary HIV-1 IsolateSemantic proximity Read ↗

Limelight on two HIV/SIV accessory proteins in macrophage infection: Is Vpx overshadowing Vpr?Semantic proximity Read ↗

Illuminating the Role of Vpr in HIV Infection of Myeloid CellsSemantic proximity Read ↗

HIV-1 Vpr-induced DNA damage activates NF-κB through ATM-NEMO independent of cell cycle arrestSemantic proximity Read ↗

Tight Interplay among SAMHD1 Protein Level, Cellular dNTP Levels, and HIV-1 Proviral DNA Synthesis Kinetics in Human Primary Monocyte-derived MacrophagesSemantic proximity Read ↗

SAMHD1-Dependent and -Independent Functions of HIV-2/SIV Vpx ProteinSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.