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Evidence for an Activation Domain at the Amino Terminus of Simian Immunodeficiency Virus Vpx

19 Nov 2009

Abstract excerpt

Vpx and Vpr are related lentiviral accessory proteins that enhance virus replication in macrophages and dendritic cells. Both proteins are packaged into virions and mediate their effects in the target cell through an interaction with an E3 ubiquitin ligase that contains DCAF1 and DDB1. When introduced into primary macrophages and dendritic cells in viruslike particles, Vpx can enhance the efficiency of a...

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Identifiers

PMID: 19923175
DOI: 10.1128/jvi.01437-09

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