Morphological study on biologically distinct vpx/vpr mutants of HIV-2.

doi:10.2152/jmi.53.271

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Article

Morphological study on biologically distinct vpx/vpr mutants of HIV-2.

The journal of medical investigation : JMI - 1 Aug 2006

Piroozmand Ahmad, Khamsri Boonruang, Fujita Mikako, Adachi Akio, Uchiyama Tsuneo

Abstract excerpt

We have previously shown that human immunodeficiency virus type 2 (HIV-2) without functional vpx and vpr genes is severely defective for viral growth in lymphocytic cells, and suggested that the virions produced in the absence of Vpx and Vpr are critically damaged. To examine the nature of replication-defect for the vpx/vpr double mutant, we quantitatively and morphologically studied the virions produced in cells...

Topics

Cell Line
DNA, Viral
Gene Products, vpr
Genes, Viral
HIV-2
Humans
Lymphocytes
Mutation
Transfection
Viral Regulatory and Accessory Proteins
Virion
vpr Gene Products, Human Immunodeficiency Virus

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Identifiers

PMID: 16953064
DOI: 10.2152/jmi.53.271

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