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Characterization of Simian Immunodeficiency Virus SIV <sub>SM</sub> /Human Immunodeficiency Virus Type 2 Vpx Function in Human Myeloid Cells

2 Oct 2008

Abstract excerpt

Human immunodeficiency virus type 2 (HIV-2)/simian immunodeficiency virus SIV(SM) Vpx is incorporated into virion particles and is thus present during the early steps of infection, when it has been reported to influence the nuclear import of viral DNA. We recently reported that Vpx promoted the accumulation of full-length viral DNA following the infection of human monocyte-derived dendritic cells (DCs). This...

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PMID: 18829761
DOI: 10.1128/jvi.01181-08

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