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Article

Human immunodeficiency virus type 1 Vpr is a positive regulator of viral transcription and infectivity in primary human macrophages.

The Journal of experimental medicine - 6 Apr 1998

Subbramanian R A, Kessous-Elbaz A, Lodge R, Forget J, Yao X J, Bergeron D, Cohen E A

Abstract excerpt

It is currently well established that HIV-1 Vpr augments viral replication in primary human macrophages. In its virion-associated form, Vpr has been suggested to aid efficient translocation of the proviral DNA into the cell nucleus. Although Vpr growth-arrests dividing T cells, the relevance of this biological activity in nondividing macrophages is unclear. Here we use Vpr-mutants to demonstrate that the...

Topics

Cell Nucleus
DNA Replication
DNA, Viral
G2 Phase
Gene Expression Regulation, Viral
Gene Products, vpr
HIV-1
Humans
Macrophages
Phenotype
RNA, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

T-Lymphocytes

Transcription, Genetic

Viral Proteins

vpr Gene Products, Human Immunodeficiency Virus

Source

Open in PubMed Open full text

Identifiers

PMID: 9529326
DOI: 10.1084/jem.187.7.1103
PMCID: PMC2212198

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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