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Article

Growth ability of human immunodeficiency virus type 1 auxiliary gene mutants in primary blood macrophage cultures.

The Journal of general virology - 1 Sept 1994

Kawamura M, Ishizaki T, Ishimoto A, Shioda T, Kitamura T, Adachi A

Abstract excerpt

A strain of human immunodeficiency virus type 1 that is strictly tropic for primary human blood cell cultures was constructed in vitro. Mutational studies on the vif, vpr, vpu and nef genes of this virus were performed to evaluate their biological functions in natural target cells. For this purpose, replication properties of mutant viruses in peripheral blood mononuclear cells (PBMCs) and macrophages (PBMPs) were...

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PMID: 8077944
DOI: 10.1099/0022-1317-75-9-2427

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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