Article
Growth ability of human immunodeficiency virus type 1 auxiliary gene mutants in primary blood macrophage cultures.
The Journal of general virology - 1 Sept 1994
Kawamura M, Ishizaki T, Ishimoto A, Shioda T, Kitamura T, Adachi A
Abstract excerpt
A strain of human immunodeficiency virus type 1 that is strictly tropic for primary human blood cell cultures was constructed in vitro. Mutational studies on the vif, vpr, vpu and nef genes of this virus were performed to evaluate their biological functions in natural target cells. For this purpo...
Topics
- Cell Line
- Cells, Cultured
- Genes, Viral
- Genome, Viral
- HIV Long Terminal Repeat
- HIV-1
- Humans
- Kinetics
- Leukemia, Promyelocytic, Acute
- Lymphocytes
- Macrophages
- Mutation
- Restriction Mapping
- Viral Structural Proteins
- Virus Replication