Article
Modulation of an outer membrane protease contributes to the virulence defect of Shigella flexneri strains carrying a mutation in the virK locus.
Infection and immunity - 1 Feb 2005
Wing Helen J, Goldman Seth R, Ally Shabeen, Goldberg Marcia B
Abstract excerpt
The Shigella actin assembly protein IcsA is removed from the bacterial surface by the protease IcsP. We show that decreased intracellular spreading of virK::Tn10 mutants is due in part to significant increases in IcsP and IcsP-mediated cleavage of IcsA and that IcsP expression is a critical determinant of Shigella virulence.
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