Article
Restricted 12p amplification and RAS mutation in human germ cell tumors of the adult testis.
The American journal of pathology - 1 Oct 2000
Roelofs H, Mostert M C, Pompe K, Zafarana G, van Oorschot M, van Gurp R J, Gillis A J, Stoop H, Beverloo B, Oosterhuis J W, Bokemeyer C, Looijenga L H
Abstract excerpt
Human testicular germ-cell tumors of young adults (TGCTs), both seminomas and nonseminomas, are characterized by 12p overrepresentation, mostly as isochromosomes, of which the biological and clinical significance is still unclear. A limited number of TGCTs has been identified with an additional high-level amplification of a restricted region of 12p including the K-RAS proto-oncogene. Here we show that the...
Topics
- Adult
- Apoptosis
- Cell Division
- Cell Survival
- Chromosomes, Human, Pair 12
- Gene Amplification
- Genes, ras
- Genetic Variation
- Germinoma
- Humans
- Male
- Mutation
- Neoplasm Invasiveness
- Neoplasm Staging