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Article

p53 inactivation by MDM2 and MDMX negative feedback loops in testicular germ cell tumors

1 Apr 2010

Abstract excerpt

Testicular germ cell tumors (TGCT) are unique in their excellent response to DNA-damaging chemotherapy. Mutation of p53 is rare in both untreated and relapsed TGCTs, suggesting that p53 fails to respond effectively against malignant transformation in germ cells. Previous studies implicated the presence of a poorly defined TGCT-specific mechanism of p53 inactivation. Here we show that disruption of p53-MDM2...

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Identifiers

PMID: 20372076
DOI: 10.4161/cc.9.7.11255

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