Article
DeltaNp73 regulates neuronal survival in vivo.
Proceedings of the National Academy of Sciences of the United States of America - 29 Sept 2009
Tissir Fadel, Ravni Aurélia, Achouri Younès, Riethmacher Dieter, Meyer Gundela, Goffinet Andre M
Abstract excerpt
Apoptosis occurs widely during brain development, and p73 transcription factors are thought to play essential roles in this process. The p73 transcription factors are present in two forms, the full length TAp73 and the N-terminally truncated DeltaNp73. In cultured sympathetic neurons, overexpression of DeltaNp73 inhibits apoptosis induced by nerve growth factor withdrawal or p53 overexpression. To probe the...
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