Article
p75-deficient trigeminal sensory neurons have an altered response to NGF but not to other neurotrophins.
Neuron - 1 Oct 1993
Davies A M, Lee K F, Jaenisch R
Abstract excerpt
The role of the common low affinity neurotrophin receptor, p75, is controversial. Studies using cell lines suggest that p75 is either essential or dispensable for neurotrophin responsiveness. To resolve this issue, we studied the survival response of developing neurons obtained from normal mouse embryos and embryos with a null mutation in the p75 gene. Embryonic cranial sensory and sympathetic neurons from mutant...
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