p75-deficient trigeminal sensory neurons have an altered response to NGF but not to other neurotrophins.

doi:10.1016/0896-6273(93)90069-4

Back to search

Article

p75-deficient trigeminal sensory neurons have an altered response to NGF but not to other neurotrophins.

Neuron - 1 Oct 1993

Davies A M, Lee K F, Jaenisch R

Abstract excerpt

The role of the common low affinity neurotrophin receptor, p75, is controversial. Studies using cell lines suggest that p75 is either essential or dispensable for neurotrophin responsiveness. To resolve this issue, we studied the survival response of developing neurons obtained from normal mouse...

Topics

Animals
Cell Survival
Crosses, Genetic
Embryo, Mammalian
Female
Male
Mice
Mice, Inbred BALB C
Mutation
Nerve Growth Factors
Nerve Tissue Proteins
Neurons, Afferent
Neurotrophin 3
Nodose Ganglion
Receptors, Nerve Growth Factor
Trigeminal Ganglion

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.