Article
Severe sensory and sympathetic neuropathies in mice carrying a disrupted Trk/NGF receptor gene.
Nature - 17 Mar 1994
Smeyne R J, Klein R, Schnapp A, Long L K, Bryant S, Lewin A, Lira S A, Barbacid M
Abstract excerpt
Nerve growth factor (NGF) induces neurite outgrowth and promotes survival of embryonic sensory and sympathetic neurons in culture. In vivo, NGF decreases the extent of naturally occurring cell death in developing sympathetic ganglia and protects cholinergic neurons of the basal forebrain and caud...
Topics
- Acetylcholinesterase
- Animals
- Brain
- Cell Count
- Ganglia, Spinal
- Ganglia, Sympathetic
- Mice
- Mice, Mutant Strains
- Mutation
- Nerve Growth Factors
- Nervous System Diseases
- Proto-Oncogene Proteins
- Receptor Protein-Tyrosine Kinases
- Receptor, trkA
- Receptors, Nerve Growth Factor
- Signal Transduction
- Stem Cells
- Sympathetic Nervous System