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Article

p75-deficient embryonic dorsal root sensory and neonatal sympathetic neurons display a decreased sensitivity to NGF.

Development (Cambridge, England) - 1 Apr 1994

Lee K F, Davies A M, Jaenisch R

Abstract excerpt

To understand the role of low-affinity neurotrophin receptor p75 in neural development, we previously generated mice carrying a null mutation in the p75 locus (Lee, K. F., Li, E., Huber, L. J., Landis, S. C., Sharpe, A. H., Chao, M. V. and Jaenisch, R. (1992) Cell 69, 737-749). To elucidate the mechanisms leading to deficits in the peripheral nervous system in p75 mutant mice, we have employed dissociated...

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Source

Identifiers

PMID: 7600951
DOI: 10.1242/dev.120.4.1027

Genes

NGF
BDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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p75-deficient embryonic dorsal root sensory and neonatal sympathetic neurons display a decreased sensitivity to NGF.PMID 7600951Read ↗

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Dependence on p75 for innervation of some sympathetic targets.Semantic proximity Read ↗

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