Article
p75-deficient embryonic dorsal root sensory and neonatal sympathetic neurons display a decreased sensitivity to NGF.
Development (Cambridge, England) - 1 Apr 1994
Lee K F, Davies A M, Jaenisch R
Abstract excerpt
To understand the role of low-affinity neurotrophin receptor p75 in neural development, we previously generated mice carrying a null mutation in the p75 locus (Lee, K. F., Li, E., Huber, L. J., Landis, S. C., Sharpe, A. H., Chao, M. V. and Jaenisch, R. (1992) Cell 69, 737-749). To elucidate the mechanisms leading to deficits in the peripheral nervous system in p75 mutant mice, we have employed dissociated...
Topics
- Animals
- Apoptosis
- Cells, Cultured
- Ganglia, Spinal
- Mice
- Mice, Mutant Strains
- Nerve Growth Factors
- Nerve Tissue Proteins
- Neurotrophin 3
- Phenotype
- Receptor, Nerve Growth Factor