Article
A Saccharomyces cerevisiae mitochondrial transcription factor, sc-mtTFB, shares features with sigma factors but is functionally distinct.
Molecular and cellular biology - 1 Apr 1995
Shadel G S, Clayton D A
Abstract excerpt
In Saccharomyces cerevisiae mitochondria, sc-mtTFB is a 341-amino-acid transcription factor required for initiation of transcription from mitochondrial DNA promoters. Specific transcription in vitro requires only sc-mtTFB and the bacteriophage-related core sc-mtRNA polymerase. Mutational analysis of sc-mtTFB has defined two regions of the protein that are important for normal function both in vivo and in vitro....
Topics
- Amino Acid Sequence
- Conserved Sequence
- DNA Mutational Analysis
- DNA, Superhelical
- DNA-Directed RNA Polymerases
- Fungal Proteins
- Mitochondria
- Mitochondrial Proteins
- Molecular Sequence Data
- Phenotype