The yeast nuclear gene MRF1 encodes a mitochondrial peptide chain release factor and cures several mitochondrial RNA splicing defects.

doi:10.1093/nar/20.23.6339

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Article

The yeast nuclear gene MRF1 encodes a mitochondrial peptide chain release factor and cures several mitochondrial RNA splicing defects.

Nucleic acids research - 11 Dec 1992

Pel H J, Maat C, Rep M, Grivell L A

Abstract excerpt

We report the molecular cloning, sequencing and genetic characterization of the first gene encoding an organellar polypeptide chain release factor, the MRF1 gene of the yeast Saccharomyces cerevisiae. The MRF1 gene was cloned by genetic complementation of a respiratory deficient mutant disturbed in the expression of the mitochondrial genes encoding cytochrome c oxidase subunit 1 and 2, COX1 and COX2. For COX1...

Topics

Amino Acid Sequence
Cloning, Molecular
Fungal Proteins
Genes, Fungal
Genetic Complementation Test
Introns
Mitochondria
Mitochondrial Proteins
Molecular Sequence Data
Mutagenesis
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Biosynthesis

RNA Splicing

Restriction Mapping

Saccharomyces cerevisiae

Saccharomyces cerevisiae Proteins

Transcription Factors

Source

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Identifiers

PMID: 1475194
DOI: 10.1093/nar/20.23.6339
PMCID: PMC334525

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1475194-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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