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Article

MCAT Elements and the TEF-1 Family of Transcription Factors in Muscle Development and Disease

25 Oct 2007

Abstract excerpt

MCAT elements are located in the promoter-enhancer regions of cardiac, smooth, and skeletal muscle-specific genes including cardiac troponin T, beta-myosin heavy chain, smooth muscle alpha-actin, and skeletal alpha-actin, and play a key role in the regulation of these genes during muscle development and disease. The binding factors of MCAT elements are members of the transcriptional enhancer factor-1 (TEF-1)...

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PMID: 17962623
DOI: 10.1161/atvbaha.107.155788

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