Article
Synergistic activation of cardiac genes by myocardin and Tbx5.
PloS one - 1 Jan 2011
Wang Chunbo, Cao Dongsun, Wang Qing, Wang Da-Zhi
Abstract excerpt
Myocardial differentiation is associated with the activation and expression of an array of cardiac specific genes. However, the transcriptional networks that control cardiac gene expression are not completely understood. Myocardin is a cardiac and smooth muscle-specific expressed transcriptional coactivator of Serum Response Factor (SRF) and is able to potently activate cardiac and smooth muscle gene expression...
Topics
- Animals
- Atrial Natriuretic Factor
- COS Cells
- Chlorocebus aethiops
- Genes, Reporter
- Humans
- Mice
- Mutation
- Myocardium
- Nuclear Proteins
- Promoter Regions, Genetic
- Protein Binding