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Article

Role of the common cytokine receptor gamma chain in cytokine signaling and lymphoid development.

Immunological reviews - 1 Dec 1995

Leonard W J, Shores E W, Love P E

Abstract excerpt

To examine the role of gamma c in lymphoid development, we have analyzed mice in which the gamma c gene was specifically inactivated by homologous recombination. These mice also serve as an animal model of human X-linked severe combined immunodeficiency (XSCID). Interestingly, gamma c knockout mi...

Topics

Animals
B-Lymphocytes
Crosses, Genetic
Genetic Vectors
Humans
Interleukin-2
Janus Kinase 1
Janus Kinase 3
Lymphoid Tissue
Mutation
Phenotype
Protein-Tyrosine Kinases
Receptors, Cytokine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Receptors, Interleukin-2

Severe Combined Immunodeficiency

Signal Transduction

T-Lymphocytes

X Chromosome

Source

Identifiers

PMID: 8825284
DOI: 10.1111/j.1600-065x.1995.tb00095.x

Genes

TSLP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8825284-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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