Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Role of the common cytokine receptor gamma chain in cytokine signaling and lymphoid development.

Immunological reviews - 1 Dec 1995

Leonard W J, Shores E W, Love P E

Abstract excerpt

To examine the role of gamma c in lymphoid development, we have analyzed mice in which the gamma c gene was specifically inactivated by homologous recombination. These mice also serve as an animal model of human X-linked severe combined immunodeficiency (XSCID). Interestingly, gamma c knockout mice exhibited a somewhat different phenotype than humans with XSCID. Absolute T-cell numbers are greatly diminished in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to B-Lymphocytes
Share to Crosses, Genetic
Share to Genetic Vectors

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mutation

Share to Phenotype

Share to Signal Transduction

Share to T-Lymphocytes

Share to X Chromosome

Source

Identifiers

PMID: 8825284
DOI: 10.1111/j.1600-065x.1995.tb00095.x

Genes

TSLP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Role of the common cytokine receptor gamma chain in cytokine signaling and lymphoid development.PMID 8825284Read ↗

The molecular basis of X-linked severe combined immunodeficiency: the role of the interleukin-2 receptor gamma chain as a common gamma chain, gamma c.Semantic proximity Read ↗

A role for thymic stromal lymphopoietin in CD4(+) T cell development.Semantic proximity Read ↗

Stat5a/b are essential for normal lymphoid development and differentiation.Semantic proximity Read ↗

Absence of an essential role for thymic stromal lymphopoietin receptor in murine B-cell development.Semantic proximity Read ↗

Shared gamma(c) subunit within the human interleukin-7 receptor complex. A molecular basis for the pathogenesis of X-linked severe combined immunodeficiency.Semantic proximity Read ↗

Of genes and phenotypes: the immunological and molecular spectrum of combined immune deficiency. Defects of the gamma(c)-JAK3 signaling pathway as a model.Semantic proximity Read ↗

Immune deficiencies due to defects in cytokine signaling.Semantic proximity Read ↗

X-linked severe combined immunodeficiency: from molecular cause to gene therapy within seven years.Semantic proximity Read ↗

Thymopoiesis and T cell development in common gamma chain-deficient dogs.Semantic proximity Read ↗

Mutation of Jak3 in a patient with SCID: essential role of Jak3 in lymphoid development.Semantic proximity Read ↗

gamma(c) cytokines provide multiple homeostatic signals to naive CD4(+) T cells.Semantic proximity Read ↗

Immune consequences of mutations in the human common gamma-chain gene.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.