Article
Delayed lymphoid repopulation with defects in IL-4-driven responses produced by inactivation of NF-ATc.
Immunity - 1 Jan 1998
Ranger A M, Hodge M R, Gravallese E M, Oukka M, Davidson L, Alt F W, de la Brousse F C, Hoey T, Grusby M, Glimcher L H
Abstract excerpt
The NF-AT family of transcription factors activates early immune response genes such as cytokines. In the adult, NF-ATc is expressed exclusively in the lymphoid system and is induced upon lymphocyte activation. NF-ATc null mutant mice die in utero of cardiac failure, precluding analysis of the ro...
Topics
- Alleles
- Animals
- B-Lymphocytes
- DNA-Binding Proteins
- Immunoglobulin E
- Immunoglobulin G
- Immunoglobulin M
- Interleukin-4
- Liver
- Lymphocyte Activation
- Lymphoid Tissue
- Mice
- Mice, Inbred BALB C
- NFATC Transcription Factors
- Nuclear Proteins