Article
Delayed lymphoid repopulation with defects in IL-4-driven responses produced by inactivation of NF-ATc.
Immunity - 1 Jan 1998
Ranger A M, Hodge M R, Gravallese E M, Oukka M, Davidson L, Alt F W, de la Brousse F C, Hoey T, Grusby M, Glimcher L H
Abstract excerpt
The NF-AT family of transcription factors activates early immune response genes such as cytokines. In the adult, NF-ATc is expressed exclusively in the lymphoid system and is induced upon lymphocyte activation. NF-ATc null mutant mice die in utero of cardiac failure, precluding analysis of the role of NF-ATc in lymphocyte activation. By using RAG-2-deficient blastocyst complementation, we now demonstrate that...
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