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Article

The product of hedgehog autoproteolytic cleavage active in local and long-range signalling.

Nature - 23 Mar 1995

Porter J A, von Kessler D P, Ekker S C, Young K E, Lee J J, Moses K, Beachy P A

Abstract excerpt

The secreted protein products of the hedgehog (hh) gene family are associated with local and long-range signalling activities that are responsible for developmental patterning in multiple systems, including Drosophila embryonic and larval tissues and vertebrate neural tube, limbs and somites. In a process that is critical for full biological activity, the hedgehog protein (Hh) undergoes autoproteolysis to...

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PMID: 7885476
DOI: 10.1038/374363a0

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