Article
The product of hedgehog autoproteolytic cleavage active in local and long-range signalling.
Nature - 23 Mar 1995
Porter J A, von Kessler D P, Ekker S C, Young K E, Lee J J, Moses K, Beachy P A
Abstract excerpt
The secreted protein products of the hedgehog (hh) gene family are associated with local and long-range signalling activities that are responsible for developmental patterning in multiple systems, including Drosophila embryonic and larval tissues and vertebrate neural tube, limbs and somites. In a process that is critical for full biological activity, the hedgehog protein (Hh) undergoes autoproteolysis to...
Topics
- Amino Acid Sequence
- Animals
- Drosophila
- Drosophila Proteins
- Hedgehog Proteins
- Hydrolysis
- Mice
- Molecular Sequence Data
- Mutation
- Peptide Fragments
- Proteins
- Signal Transduction