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Article

An acylatable residue of Hedgehog is differentially required in Drosophila and mouse limb development.

Developmental biology - 1 May 2001

Lee J D, Kraus P, Gaiano N, Nery S, Kohtz J, Fishell G, Loomis C A, Treisman J E

Abstract excerpt

The Drosophila Hedgehog protein and its vertebrate counterpart Sonic hedgehog are required for a wide variety of patterning events throughout development. Hedgehog proteins are secreted from cells and undergo autocatalytic cleavage and cholesterol modification to produce a mature signaling domain. This domain of Sonic hedgehog has recently been shown to acquire an N-terminal acyl group in cell culture. We have...

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PMID: 11319862
DOI: 10.1006/dbio.2001.0218

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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