Article
Structure of the protein core of the glypican Dally-like and localization of a region important for hedgehog signaling.
Proceedings of the National Academy of Sciences of the United States of America - 9 Aug 2011
Kim Min-Sung, Saunders Adam M, Hamaoka Brent Y, Beachy Philip A, Leahy Daniel J
Abstract excerpt
Glypicans are heparan sulfate proteoglycans that modulate the signaling of multiple growth factors active during animal development, and loss of glypican function is associated with widespread developmental abnormalities. Glypicans consist of a conserved, approximately 45-kDa N-terminal protein core region followed by a stalk region that is tethered to the cell membrane by a glycosyl-phosphatidylinositol anchor....
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