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Article

The Adventures of Sonic Hedgehog in Development and Repair. III. Hedgehog processing and biological activity

1 Feb 2008

Abstract excerpt

The Hedgehog (Hh) family of secreted proteins is necessary for aspects of the development and maintenance of the gastrointestinal tract. Hh is thought to function as a morphogen, a mitogen, a cell survival factor, and an axon guidance factor. Given its wide role in development, as well as in a variety of disease states, understanding the regulation of Hh function and activity is critically important. However, the...

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PMID: 18239057
DOI: 10.1152/ajpgi.00564.2007

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