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Article

Association of Sonic Hedgehog with the extracellular matrix requires its zinc-coordination center.

BMC molecular and cell biology - 16 Apr 2021

Jägers Carina, Roelink Henk

Abstract excerpt

BACKGROUND: Sonic Hedgehog (Shh) has a catalytic cleft characteristic for zinc metallopeptidases and has significant sequence similarities with some bacterial peptidoglycan metallopeptidases defining a subgroup within the M15A family that, besides having the characteristic zinc coordination motif, can bind two calcium ions. Extracellular matrix (ECM) components in animals include heparan-sulfate proteoglycans,...

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Identifiers

PMID: 33863273
DOI: 10.1186/s12860-021-00359-5
PMCID: PMC8052667

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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