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Article

Evidence for an expansion-based temporal Shh gradient in specifying vertebrate digit identities.

Cell - 20 Aug 2004

Harfe Brian D, Scherz Paul J, Nissim Sahar, Tian Hua, McMahon Andrew P, Tabin Clifford J

Abstract excerpt

The zone of polarizing activity (ZPA) in the posterior limb bud produces Sonic Hedgehog (Shh) protein, which plays a critical role in establishing distinct fates along the anterior-posterior axis. This activity has been modeled as a concentration-dependent response to a diffusible morphogen. Using recombinase base mapping in the mouse, we determine the ultimate fate of the Shh-producing cells. Strikingly, the...

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Identifiers

PMID: 15315763
DOI: 10.1016/j.cell.2004.07.024

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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