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Article

Targeted Modulation of MGMT: Clinical Implications

15 Jan 2006

Abstract excerpt

O(6)-Methylguanine DNA methyltransferase (MGMT) has been studied for >20 years as a gene that is associated with the mutagenicity and cytotoxicity induced by either methylating carcinogens or alkylating (methylating and chloroethylating) therapeutic agents. Pioneering studies of alkylating agents identified alkylated guanine at the O(6) position, the substrate of MGMT, as a potentially promutagenic and lethal...

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PMID: 16428468
DOI: 10.1158/1078-0432.ccr-05-2543

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