An etoposide-induced block in vaccinia virus telomere resolution is dependent on the virus-encoded DNA ligase.

doi:10.1128/JVI.69.4.2082-2091.1995

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Article

An etoposide-induced block in vaccinia virus telomere resolution is dependent on the virus-encoded DNA ligase.

Journal of virology - 1 Apr 1995

DeLange A M, Carpenter M S, Choy J, Newsway V E

Abstract excerpt

Etoposide, an inhibitor of the breakage-reunion reaction associated with cellular type II DNA topoisomerases, was shown to inhibit plaque formation of vaccinia virus. This drug had a major effect on the segregation of newly replicated DNA concatemers. Gene expression and the initiation and elongation phases of viral DNA replication were essentially unaffected. Pulsed-field gel electrophoresis of viral DNA...

Topics

Amino Acid Sequence
Amsacrine
Animals
Base Sequence
Cells, Cultured
Chlorocebus aethiops
DNA Ligases
DNA Replication
DNA, Viral
Drug Resistance
Etoposide
Gene Expression

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutation

Telomere

Thymidine Kinase

Vaccinia virus

Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 7884854
DOI: 10.1128/JVI.69.4.2082-2091.1995
PMCID: PMC188874

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7884854-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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