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Article

An etoposide-induced block in vaccinia virus telomere resolution is dependent on the virus-encoded DNA ligase.

Journal of virology - 1 Apr 1995

DeLange A M, Carpenter M S, Choy J, Newsway V E

Abstract excerpt

Etoposide, an inhibitor of the breakage-reunion reaction associated with cellular type II DNA topoisomerases, was shown to inhibit plaque formation of vaccinia virus. This drug had a major effect on the segregation of newly replicated DNA concatemers. Gene expression and the initiation and elongation phases of viral DNA replication were essentially unaffected. Pulsed-field gel electrophoresis of viral DNA...

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Identifiers

PMID: 7884854
DOI: 10.1128/JVI.69.4.2082-2091.1995
PMCID: PMC188874

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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