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Article

Vaccinia virus DNA ligase recruits cellular topoisomerase II to sites of viral replication and assembly.

Journal of virology - 1 Jun 2008

Lin Y-C James, Li Jianhong, Irwin Chad R, Jenkins Heather, DeLange Luke, Evans David H

Abstract excerpt

Vaccinia virus replication is inhibited by etoposide and mitoxantrone even though poxviruses do not encode the type II topoisomerases that are the specific targets of these drugs. Furthermore, one can isolate drug-resistant virus carrying mutations in the viral DNA ligase and yet the ligase is not known to exhibit sensitivity to these drugs. A yeast two-hybrid screen was used to search for proteins binding to...

Topics

Antibodies, Monoclonal
Antineoplastic Agents, Phytogenic
Cell Line
Cell Nucleus
DNA Ligases
DNA Topoisomerases, Type II
DNA, Complementary
DNA, Viral
Dose-Response Relationship, Drug
Etoposide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Mutation

Recombinant Fusion Proteins

Transfection

Two-Hybrid System Techniques

Vaccinia virus

Viral Plaque Assay

Virus Assembly

Source

Open in PubMed Open full text

Identifiers

PMID: 18417590
DOI: 10.1128/JVI.02723-07
PMCID: PMC2395158

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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