Article
An antitumor drug-induced topoisomerase cleavage complex blocks a bacteriophage T4 replication fork in vivo.
Molecular and cellular biology - 1 Jan 2000
Hong G, Kreuzer K N
Abstract excerpt
Many antitumor and antibacterial drugs inhibit DNA topoisomerases by trapping covalent enzyme-DNA cleavage complexes. Formation of cleavage complexes is important for cytotoxicity, but evidence suggests that cleavage complexes themselves are not sufficient to cause cell death. Rather, active cellular processes such as transcription and/or replication are probably necessary to transform cleavage complexes into...
Topics
- Amsacrine
- Antineoplastic Agents
- Bacteriophage T4
- Base Sequence
- Binding Sites
- DNA Repair
- DNA Replication
- DNA Topoisomerases, Type II
- DNA, Viral
- Deoxyribonucleases, Type II Site-Specific
- Escherichia coli
- Mutation
- Nucleic Acid Conformation
- Plasmids
- Recombination, Genetic
- Regulatory Sequences, Nucleic Acid
- Replication Origin
- Topoisomerase II Inhibitors