Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

DNA ligase gene disruptions can depress viral growth and replication in poxvirus-infected cells.

Virus research - 1 Aug 1998

Parks R J, Winchcombe-Forhan C, DeLange A M, Xing X, Evans D H

Abstract excerpt

Poxvirus-encoded DNA ligases are assumed to play a role in viral DNA replication; however mutational inactivation of vaccinia ligase has not been reported to affect viral growth rates in culture. This communication re-examines this surprising aspect of poxviral biology using both Shope fibroma virus (SFV) and vaccinia virus. SFV and vaccinia ligase deficiencies create essentially identical phenotypes. In...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Line
Share to DNA, Viral
Share to Genes, Viral

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mutation

Share to Phenotype

Share to Rabbits

Share to Recombination, Genetic

Share to Virus Replication

Source

Identifiers

PMID: 9783462
DOI: 10.1016/s0168-1702(98)00055-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

DNA ligase gene disruptions can depress viral growth and replication in poxvirus-infected cells.PMID 9783462Read ↗

Poxvirus DNA topoisomerase knockout mutant exhibits decreased infectivity associated with reduced early transcription.Semantic proximity Read ↗

Vaccinia virus DNA ligase recruits cellular topoisomerase II to sites of viral replication and assembly.Semantic proximity Read ↗

Predicted poxvirus FEN1-like nuclease required for homologous recombination, double-strand break repair and full-size genome formation.Semantic proximity Read ↗

Replicating poxviruses for human cancer therapySemantic proximity Read ↗

Evasion of the Innate Immune Type I Interferon System by Monkeypox VirusSemantic proximity Read ↗

Identification of Poxvirus Genome Uncoating and DNA Replication Factors with Mutually Redundant RolesSemantic proximity Read ↗

Vaccinia virus-encoded ribonucleotide reductase subunits are differentially required for replication and pathogenesis.Semantic proximity Read ↗

Vaccinia virus uracil DNA glycosylase has an essential role in DNA synthesis that is independent of its glycosylase activity: catalytic site mutations reduce virulence but not virus replication in cultured cells.Semantic proximity Read ↗

Deletion of the Vaccinia Virus B1 Kinase Reveals Essential Functions of This Enzyme Complemented Partly by the Homologous Cellular Kinase VRK2Semantic proximity Read ↗

The poxviral RING protein p28 is a ubiquitin ligase that targets ubiquitin to viral replication factories.Semantic proximity Read ↗

Vaccinia virus DNA replication: a short review.Semantic proximity Read ↗

Comparative Analysis of Poxvirus Orthologues of the Vaccinia Virus E3 Protein: Modulation of Protein Kinase R Activity, Cytokine Responses, and Virus PathogenicitySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.