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Article

Genetic susceptibility to type I diabetes: a review.

Journal of autoimmunity - 1 Apr 1990

Tait B D

Abstract excerpt

There is evidence that Type I diabetes is a genetically and environmentally determined disease. Among the genetic influences the HLA system appears to play a dominant role. HLA-DQ has been strongly implicated as the primary responsible locus by the recent discovery that position 57 in the polymorphic first domain of the DQB chain appears to be a critical residue in conferring susceptibility. DQB products which...

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Source

Identifiers

PMID: 2187458
DOI: 10.1016/s0896-8411(09)90003-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

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Genetic susceptibility to type I diabetes: a review.PMID 2187458Read ↗

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HLA-DQ beta gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus.Semantic proximity Read ↗

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A new model defines the minimal set of polymorphism in HLA-DQ and -DR that determines susceptibility and resistance to autoimmune diabetes.Semantic proximity Read ↗

HLA-DQB 1 codon 57 and genetic susceptibility to type 1 (insulin-dependent) diabetes mellitus in French children.Semantic proximity Read ↗

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Human leukocyte antigen class II polymorphisms and genetic susceptibility of IDDM in Egyptian children.Semantic proximity Read ↗

HLA-DQA1 and DQB1 gene polymorphisms in type I diabetic patients from central Italy and their use for risk prediction.Semantic proximity Read ↗

HLA-DQ beta sequence polymorphism and genetic susceptibility to IDDM.Semantic proximity Read ↗

The combination of several polymorphic amino acid residues in the DQalpha and DQbeta chains forms a domain structure pattern and is associated with insulin-dependent diabetes mellitus.Semantic proximity Read ↗

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