Article
Polymorphic amino acid variations in HLA-DQ are associated with systematic physical property changes and occurrence of IDDM. Members of the Swedish Childhood Diabetes Study.
Diabetes - 1 Jan 1995
Sanjeevi C B, Lybrand T P, DeWeese C, Landin-Olsson M, Kockum I, Dahlquist G, Sundkvist G, Stenger D, Lernmark A
Abstract excerpt
The association between human leukocyte antigen (HLA) and insulin-dependent diabetes was studied in a large population-based investigation using genotyping of 425 new-onset patients, 0-14 years of age, and 367 matched control subjects. As many as 97% of patients compared with 75% of control subjects were positive for one or several of DQA1*0301, DQA1*0501, DQB1*0302, or DQB1*0201. Asp-57 DQB was present among 28%...
Topics
- Adolescent
- Amino Acid Sequence
- Amino Acids
- Arginine
- Aspartic Acid
- Child
- Child, Preschool
- Diabetes Mellitus, Type 1
- Female
- Gene Amplification
- Genotype