Analysis of critical residues of HLA-DQ6 molecules in insulin-dependent diabetes mellitus.

doi:10.1111/j.1399-0039.1997.tb02836.x

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Article

Analysis of critical residues of HLA-DQ6 molecules in insulin-dependent diabetes mellitus.

Tissue antigens - 1 Jul 1997

Sanjeevi C B, DeWeese C, Landin-Olsson M, Kockum I, Dahlquist G, Lernmark A, Lybrand T P

Abstract excerpt

Among DQ6 molecules, DQA1*0102-DQB1*0602 is negatively associated with insulin-dependent diabetes mellitus (IDDM), but DQA1*0102-DQB1*0604 shows a neutral to positive association in Swedish children with IDDM. The aim of this study was to identify critical DQB1 residues that may account for the d...

Topics

Adolescent
Autoantibodies
Child
Child, Preschool
Diabetes Mellitus, Type 1
Genotype
HLA-DQ Antigens
HLA-DQ alpha-Chains
Humans
Infant
Infant, Newborn
Polymerase Chain Reaction
Polymorphism, Genetic
Polymorphism, Restriction Fragment Length
Protein Conformation
T-Lymphocytes

Source

Open in PubMed

Identifiers

PMID: 9243758
DOI: 10.1111/j.1399-0039.1997.tb02836.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9243758-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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