TP53 gene mutations in gastric carcinoma detected by polymerase chain reaction/single-strand conformation polymorphism analysis of archival material.

Abstract excerpt

TP53 gene mutations, one of the most common alterations described in human tumors, have also been detected in gastric carcinoma, and shown to occur rather late in disease progression. A better assessment of the prognostic value of TP53 gene mutations can be obtained by examining archival material, as this allows stored cases with well-defined histories to be monitored. We performed immunohistochemical and...

Topics

• Aged
• Base Sequence
• Female
• Genes, p53
• Humans
• Immunohistochemistry
• Male
• Middle Aged
• Molecular Sequence Data
• Mutation
• Polymerase Chain Reaction