Article
p53 immunoreactivity and single-strand conformational polymorphism analysis often fail to predict p53 mutational status.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Jan 1999
Tolbert D M, Noffsinger A E, Miller M A, DeVoe G W, Stemmermann G N, Macdonald J S, Fenoglio-Preiser C M
Abstract excerpt
The intent of this study was to investigate the ability of p53 expression and single-strand conformational polymorphism analysis (SSCP) to predict p53 mutational status in archival, paraffin-embedded tissues of gastric cancer. We evaluated paraffin-embedded tissues from 78 patients with advanced...
Topics
- Base Sequence
- DNA, Single-Stranded
- Forecasting
- Gene Frequency
- Humans
- Immunohistochemistry
- Molecular Conformation
- Mutation
- Polymorphism, Genetic
- Polymorphism, Single-Stranded Conformational
- Tumor Suppressor Protein p53